Effect of Grewia mollis Stem Bark Extract on Gonadal Function of Wistar Rats

Abstract

Grewia mollis (G. mollis) stem bark is used traditionally as a natural food additive in baked foods and condiments. However, there is no sufficient information on the effect of the stem bark on the gonadal organs in rodents. The aim of this study is to determine the effect of dietary administration of G. mollis stem bark in rats. The effect of subchronic dietary administration of G. mollis stem extract on gonadal organs was evaluated in male and female Wistar rats. The animals were assessed on behaviour, body weight and food intake, and serum gonadal hormone concentration, and the gonadal organs were assessed for histopathological changes. The results showed no behavioural changes in rats administered G. mollis stem bark extract. Administration of G. mollis stem bark extract caused no alteration in the parameters determined, except in the male groups administered 1.5% G. mollis stem bark extract, where serum luteinizing hormone was elevated. Thus, dietary administrations of G. mollis stem bark extract caused subtle or no effect on the gonadal organs of Wistar rats. This suggests that G. mollis stem bark is safe for consumption as a thickener in food and related products. The findings support the traditional use of G. mollis stem bark extract in locally baked foods and condiments.